Atopic eczema is one of the most common chronic inflammatory skin diseases, with a prevalence of at least 10% in children and 0.5–1% in adults. Basically, a deficit of n-6 essential fatty acids (EFAs) characterised by increased trans-epidermal water loss (TEWL) leads to an inflammatory skin condition-atopic dermatitis(AD) or Eczema.Symptoms include pruritus (itching), inflammation, skin sensitivity, and dryness. AD is a frequent issue for individuals of color, though it may be under recognized.
Although the pathophysiology, pathomechanisms, prevention, and treatment of atopic eczema of AD has not been fully elucidated, it is currently believed to be due to a combination of epidermal barrier dysfunction, immune dysregulation, and environmental factors.There has been enough evidence of low blood EFA concentrations to exceptionally high doses of linoleic acid. More recently, it has been established that there is no deficit of linoleum acid in atopic eczema. Concentrations of linoleic acid instead tend to be elevated in blood, milk, and adipose tissue of patients with atopic eczema, whereas concentrations of linoleic acid metabolites are substantially reduced.This suggests reduced conversion of linoleic acid to gamma-linolenic acid (GLA). In most but not all studies, administration of GLA has been found to improve the clinically assessed skin condition, the objectively assessed skin roughness, and the elevated blood catecholamine concentrations of patients with atopic eczema. Atopic eczema may be a minor inherited abnormality of EFA metabolism.
Natural Cure for Eczema
Therapy for Eczema or AD is based on reducing pruritus and inflammation, and normalizing skin surface lipids, particularly ceramides. In this context, Evening primrose oil (EPO) and borage seed oil (BO) are two plants that have been frequently touted as a treatment for eczema.
A deficiency in essential fatty acids of the skin is one factor suspected of playing a role in eczema. It has been hypothesized that a defect or deficiency in certain enzymes may result in a deficiency of GLA in the skin. GLA is a type of ω-6 fatty acid. While some ω-6 fatty acids promote inflammation (such as linoleic acid and arachidonic acid), GLA appears to reduce inflammation. A deficiency of GLA in the skin may thus result in increased inflammation. EPO contains 8% to 10% GLA and Borage seed oil contains at least 23% GLA.
Dietary recommendations for Eczema
Probiotics are defined as “live microorganisms (e.g., bacteria) that are either the same as or similar to microorganisms found naturally in the human body and may be beneficial to health. This microbiota not only promotes food digestion, but also influences local and global immunity. In healthy bodies, the gut flora is dominated by lactobacilli. In contrast, the gut flora of allergy-prone bodies has been noted to have higher numbers of Gram-negative bacteria and Staphylococcus aureus. In the context of reduced colonic T-regulatory cells among individuals with a poorly developed microbiota, the potential for allergy protection is reduced, possibly predisposing an individual to Atopic dermatitis (AD) commonly referred to as Eczema.
A number of studies have evaluated a possible link between vitamin D deficiency and AD. From an epidemiologic standpoint, studies have shown a higher prevalence of AD in association with higher geographic latitude, which correlates to less sun exposure and therefore the possibility of less vitamin D production Vitamin D has also been evaluated in the context of phototherapy. In one study of narrow-band UVB treatment, therapy was found to significantly increase serum calcidiol. At the same time, a significant increase was noted in antimicrobial peptide expression in healing skin lesions.
Oatmeal, particularly avenanthramides, a newly discovered oat fraction, may be of particular value in restoring the cutaneous barrier and reducing symptoms of AD. . Licorice, which has some skin-lightening activity, may be helpful in patients with postinflammatory hyperpigmentation (PIH).